JuniperPublishers-Global Journal of Nanomedicine

  Global Journal of Nanomedicine-Juniper publishers Introduction Zinc oxide is a material having enormous application in the field of medicine, dentistry and cosmetics. It is an inorganic white colored solid insoluble in water and currently listed as Generally Listed As Safe material (GRAS) by food and drug administration. The nanoparticles of ZnO has found enormous application in the field of medicine and cosmetics [ 1 , 2 ]. At the same time, there is also raising issues on toxicity of ZnO nanoparticles and their subsequent applications in the field of medicine [ 3 , 4 ]. The organic stabilizers used in the synthesis of metal oxide nanoparticles in general and ZnO nanoparticles in particular are known to possess toxicity, hence are non-biocompatible and most of them are insoluble in water. The common stabilizing agents like hexadecylamine, troctylphosphine oxide, alkylpyridine, organic thiols, oleic acids etc are known to cause toxicity [ 5 ]. Colloidal Z...

  Global Journal of Nanomedicine-Juniper publishers Introduction Cancer is a complex genetic disease [1] posing a major threat to mankind worldwide. Though major development has been observed in the field of chemotherapy in the recent years but chemotherapy suffers due to lack of selectivity and resistance to multiple drugs. Thus exploration of versatile field of nanotechnology may help in the introduction of alternative targeted therapy for battling cancer. Nanoparticles provide a perfect platform for drug delivery to cancer cells. In fact use of nanoparticles provides some major advantages which include a. Targeted delivery to the tissue of interest, b. Reduction in overall side effects of the drug, and c. Increased biocompatibility [2] . Thus use of engineered nanoparticles can enhance the efficacy of the drug and also minimize the side-effects in cancer bearers. Various carrier systems are now being exploited to develop suitable d...

  Global Journal of Nanomedicine-Juniper publishers Introduction Particles with sizes between 1 and 100nm are termed as nanoparticles and are used commercially across several industrial processes. Since last four decades, different varieties of nanostructures are produced and among them the market potential of AgNPs is predicted to rise from recent 0.79 billion to $2.54 billion by 2022 [ 1 ]. Different mode of applications of AgNPs makes them bioavailable in the environment. Soil environment are polluted by means of land application for biosolids wastewater treatment, accidental spills, applications of agrochemicals (e.g., nano-pesticides, fertilizers, and herbicides), washing and aging silver-containing products [ 2 - 4 ]. Higher exposure of AgNPs to different plants leads to penetration of the nanoparticles into the plants cells. The interference of AgNPs during DNA repair was the most detrimental one which finally leads to blockage of synthesis of DNA. Depolymeriz...

Global Journal of Nanomedicine-Juniper publishers   Introduction The sensing of biologically significant small molecules and metal ions is vitally important in the areas of health, environment, food and safety. The development of sensors for these important analytes involves precise architectural design for binding of analytes that induces a change in optical or electrochemical behavior of the sensing component. Although, development of molecular sensors has attracted tremendous attention for selective and sensitive detection, their performance under variable conditions of pH, temperature, solvents, ionic strength along with photo stability and biocompatibility restricts their practical utilization [ 1 ]. Use of nano materials has emerged as a viable alternative to molecular sensors due to ease of synthesis, physicochemical malleability, high surface area and possibilities of coupling with molecules of known bio recognition capability [ 2 ]. Peculiar properti...

  Global Journal of Nanomedicine-Juniper publishers Introduction Studies on the effects of metals on autoimmune diseases such as multiple sclerosis (MS) started about 36 years ago [ 1 ]. Researchers have realized that types of nutrition and diets containing certain metals such as zinc and magnesium can be involved in improving MS symptoms such as muscle signals and thus, today, many physicians take into account level of such metals in the body. Shortage of metals such as zinc, magnesium and calcium can aggravate MS symptoms; however, such deficiencies can be overcome through nutrition and dietary habits, which can also be helpful in improving symptoms of the disease. Accordingly, increased levels of metals such as cadmium, copper, iron, lead and reduced levels of metals such as magnesium, zinc and calcium are considered to be characteristic markers of the disease and known to be involved in the etiology of MS by researchers [ 2 ]. Since within the course of MS, ...